Kapoor, Mohit published the artcile77Carbon Dioxide-Mediated C(sp2)-H Arylation of Primary and Secondary Benzylamines, Safety of 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, the main research area is benzylamine aryl iodide carbon dioxide palladium regioselective arylation catalyst; arylbenzylamine ortho preparation.
C-C bond formation by transition metal-catalyzed C-H activation has become an important strategy to fabricate new bonds in a rapid fashion. Despite the pharmacol. importance of ortho-arylbenzylamines, however, effective ortho-C-C bond formation of free primary and secondary benzylamines using PdII remains an outstanding challenge. Presented herein is a new strategy for constructing ortho-arylated primary and secondary benzylamines mediated by carbon dioxide (CO2). The use of CO2 with Pd is critical to allowing this transformation to proceed under relatively mild conditions, and mechanistic studies indicate that it (CO2) is directly involved in the rate-determining step. Furthermore, the milder temperatures furnish free amine products that can be directly used or elaborated without the need for deprotection. In cases where diarylation is possible, an interesting chelate effect is shown to facilitate selective monoarylation.
Journal of the American Chemical Society published new progress about Aryl iodides Role: RCT (Reactant), RACT (Reactant or Reagent). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Safety of 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem