Pan, Wan-Chen published the artcileAn efficient synthesis of 6-benzyl-2-arylthieno[2,3-d]pyrimidin-4(3H)-ones catalyzed by HCl involving a Friedel-Crafts alkylation reaction, Formula: C9H10O3, the main research area is benzyl aryl thienopyrimidinone preparation; aminothiophenecarboxamide aldehyde tandem condensation cyclization Friedel Crafts HCl catalyst.
Aldehydes could underwent not only the subsequent condensation and cyclization with 2-aminothiophene-3-carboxamides to build a pyrimidine ring, but also a Friedel-Crafts alkylation reaction with thiophene moiety to gave unexpected 6-benzyl-2-arylthieno[2,3-d]pyrimidin-4(3H)-ones I [R1 = H, Cl, F, Me, MeO; R2 = H, Cl, F, MeO; Ar = Ph, 4-MeC6H4, 4-EtC6H4, 4-n-PrC6H4, 4-ClC6H4] and II [R3 = 2-MeOC6H4, 2-Br-4-FC6H3, 2-furyl, etc.] in good yields catalyzed by concentrated HCl.
Journal of Heterocyclic Chemistry published new progress about Condensation reaction. 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Formula: C9H10O3.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem