Laufersweiler, Michael C. published the artcileCorrelation of chemical structure with reproductive and developmental toxicity as it relates to the use of the threshold of toxicological concern, Formula: C11H12O3, the main research area is structure toxicity correlation reproduction development threshold toxicol.
In the absence of toxicol. data on a chem., the threshold of toxicol. concern (TTC) approach provides a system to estimate a conservative exposure below which there is a low probability of risk for adverse health effects. The original toxicol. dataset underlying the TTC was based on NOELs from repeat dose studies. Subsequently there have been several efforts to assess whether or not these limits are also protective for reproductive/developmental effects. This work expands the database of chems. with reproductive and developmental data, presents these data in a comprehensive and transparent format and groups the chems. according to the TTC “”Cramer Class”” rules. Distributions of NOAELs from each of these classes were used to assess whether the previously proposed TTC values based on repeat dose data are protective for reproductive/developmental toxicity endpoints as well. The present anal. indicates that, for each Cramer Class, the reproductive and developmental endpoints would be protected at the corresponding general TTC tiers derived by .
Regulatory Toxicology and Pharmacology published new progress about C28-34 fatty acids Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Formula: C11H12O3.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem