Chen, Liang published the artcileDouble C-S bond formation via multiple Csp3-H bond cleavage: synthesis of 4-hydroxythiazoles from amides and elemental sulfur under metal-free conditions, Related Products of isoquinoline, the main research area is hydroxythiazole preparation green chem; acetamide sulfur sulfuration cyclization carbon hydrogen bond cleavage.
A novel and efficient approach for the synthesis of 4-hydroxythiazoles I (R1 = Ph, 1H-indol-3-yl, 1-naphthyl, etc.; R2 = Ph, furan-2-yl, benzo[b]thiophen-2-yl, etc.) from amides R1CH2C(O)NHCH2C(O)R2 and elemental sulfur has been developed. In the presence of P2O5, DMSO and HMPA, this metal-free protocol proceeds smoothly and tolerates a spectrum of functional groups. Furthermore, this strategy involves the process of double Csp3-S bond formation through the cleavage of multiple Csp3-H bonds for the first time.
Organic & Biomolecular Chemistry published new progress about C-H bond cleavage. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Related Products of isoquinoline.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem