Felicetti, Tommaso published the artcileSustainable, three-component, one-pot procedure to obtain active anti-flavivirus agents, Product Details of C9H10O3, the main research area is pyridobenzothiazolone preparation antiflaviviral NS5 polymerase inhibition Dengue Zika antitumor; Antiviral agents; Dengue inhibitors; NS5 polymerase; One-pot procedure; Three-component reaction (3CR); Zika inhibitors.
The development of a new and sustainable three-component reaction (3CR) that can be combined with a basic hydrolysis in a one-pot procedure has been reported to obtain the pyridobenzothiazole (PBTZ) scaffold, thus reducing the number of synthetic steps, improving yields and saving time. 3CR was significantly explored in order to demonstrate its wide scope by using different starting materials. Taking advantage of these procedures, a new set of PBTZ analogs was synthesized and tested as anti-DENV-2 and anti-ZIKV agents. Compound I inhibited DENV-2 NS5 polymerase with an IC50 of 10.4μM and represented the best anti-flavivirus compound of the new series by inhibiting DENV-2- and ZIKV-infected cells with EC50 values of 1.2 and 5.0μM, resp., that translates into attractive selectivity indexes (SI – 83 and 20, resp.). These results strongly reaffirm PBTZ derivatives as promising anti-flavivirus agents that now can be synthesized through a convenient and sustainable 3CR in order to obtain more potent compounds for further pre-clin. development studies.
European Journal of Medicinal Chemistry published new progress about Antitumor agents. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Product Details of C9H10O3.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem