Ke, Zhengang published the artcileAlcohol promoted N-methylation of anilines with CO2/H2 over a cobalt catalyst under mild conditions, Application of 4-Methoxy-N-methylaniline, the main research area is amine methylation carbon dioxide hydrogen cobalt catalyst ethanol promoter.
Herein, an alc. (e.g., ethanol) promoted strategy for the N-methylation of anilines with CO2/H2 with high efficiency under mild conditions (e.g., 125°), which is achieved over a cobalt catalytic system composed of Co(OAc)2·4H2O, triphos and Sn(OTf)2 was presented. This catalytic system has a broad substrate scope and is tolerant toward a wide range of anilines and N-Me anilines, and a series of N,N-di-Me anilines were obtained in high yields. Mechanism investigation indicates that the alc. solvent shifts the equilibrium of CO2 hydrogenation by forming an alkyl formate, which further reacts with the amine to produce N-formamide, and Sn(OTf)2 promotes the deoxygenative hydrogenation of N-formamides to afford N-methylamines. This is the first example of the N-methylation of amines with CO2/H2 over a cobalt catalytic system, which shows comparable performance to the reported Ru catalysts and may have promising applications.
Green Chemistry published new progress about Anilines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Application of 4-Methoxy-N-methylaniline.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem