Reddy, G. Mahesh Kumar published the artcileDevelopment and validation of stability indicating UPLC method for the determination of diatrizoic acid related impurities in bulk and finished formulations, Application In Synthesis of 117-96-4, the main research area is diatrizoic acid finished formulation UPLC method stability development.
A simple, sensitive and stability indicating RP-UPLC method was developed and validated for the estimation of Diatrizoic acid and its related impurities in bulk and finished dosage forms by using Acquity UPLC CSH C18 (1.7μm 100*2.1 mm) column with 0.05% formic acid in milli-Q water and acetonitrile as mobile phase in gradient elution mode with a run time of 12 min at a wavelength of 238 nm. Drug was subjected to forced degradation and the samples were analyzed by the developed method to establish the stability indicating power of the method. The LOD values were 0.01, 0.009, 0.012, 0.011μ g mL-1 and the LOQ values were 0.04, 0.027, 0.035, 0.034μg mL-1 resp. for DTA and its 3 related substances. The average recovery values for DTA and impurities were found to be in the range of 97.4-101.9%. The developed method was linear over a range of 0.03- 0.3μg mL-1 for DTA impurities.
Journal of Applicable Chemistry (Lumami, India) published new progress about Acetonitriles Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 117-96-4 belongs to class isoquinoline, name is Diatrizoic Acid, and the molecular formula is C11H9I3N2O4, Application In Synthesis of 117-96-4.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem