Nakamura, Itaru published the artcileSynthesis of meta-Substituted Anilines via Copper-Catalyzed [1,3]-Methoxy Rearrangement, HPLC of Formula: 151-10-0, the main research area is methoxyaniline nucleophile copper catalyst methoxy rearrangement Michael addition cascade; meta substituted aniline preparation.
Meta-Substituted anilines were efficiently synthesized via copper-catalyzed [1,3]-methoxy rearrangement of N-methoxyanilines followed by Michael addition of nucleophiles to the in situ generated ortho-quinol imine. The present reaction exhibits excellent applicability of para-substituents, such as vinyl, methylthio, ester, and bromo, and carbon nucleophiles, such as 1,3,5-trimethoxybenzene, N-methylindole, and di-Me malonate. Thus, the present rearrangement can resolve problems stemming from oxidation reactions, such as the use of stoichiometric amounts of oxidants and low compatibility of electron-withdrawing groups.
Organic Letters published new progress about Anilines Role: SPN (Synthetic Preparation), PREP (Preparation) (meta-substituted). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, HPLC of Formula: 151-10-0.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem