Croft, Rosemary A. published the artcileCatalytic Friedel-Crafts Reactions on Saturated Heterocycles and Small Rings for sp3-sp2 Coupling of Medicinally Relevant Fragments, COA of Formula: C8H10O2, the main research area is heterocycle saturated nucleophile Lewis acid Friedel Crafts reaction catalyst; cyclobutane nucleophile Lewis acid Friedel Crafts reaction catalyst; diaryl geminal preparation.
Gem-Diarylheterocycles display a wide range of biol. activity. Here we present a systematic study into the formation of 4- to 6-membered O- and N-heterocycles and cyclobutanes bearing the diaryl motif through a catalytic Friedel-Crafts reaction from the corresponding benzylic alcs. 3,3-Diaryltetrahydrofurans, 4,4-diaryltetrahydropyrans, 3,3-diarylpyrrolidines, 4,4-diaryl-piperidines, as well as diarylcyclobutanes are examined, with results for 3,3-diaryloxetanes and 3,3-diarylazetidines presented for comparison. Three catalytic systems are investigated for each substrate [Ca(II), Li(I) and Fe(III)], across preinstalled aromatic groups of differing electronic character. In most cases examined, the diaryl product is obtained directly from the alc. with good yields using the most appropriate catalyst system. In the absence of a nucleophile, the olefins from the 5- and 6-membered substrates by elimination of water are obtained under the same reaction conditions.
European Journal of Organic Chemistry published new progress about Alkenes Role: SPN (Synthetic Preparation), PREP (Preparation) (Heterocyclic). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, COA of Formula: C8H10O2.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem