Tao, Lei published the artcileSynthesis of Carboxylic Acids, Esters, and Amides from 1,1-Dibromoalkenes via Oxidation of Alkynyl Boronate Intermediates, Synthetic Route of 104-01-8, the main research area is carboxylic acid preparation; dibromoalkene oxone Corey Fuchs reaction oxidation; ester preparation; alc oxone dibromoalkene Corey Fuchs reaction oxidation; amide preparation; amine oxone dibromoalkene Corey Fuchs reaction oxidation.
An efficient and practical method for the synthesis of carboxylic acids RCH2COOH (R = cyclohexyl, biphenyl-4-yl, thiophen-2-yl, etc.), esters RCH2C(O)OR1 (R1 = Me, Bn, cyclopropylmethyl, etc.), and amides RCH2C(O)NR2R3 [R2 = H, Et, i-Pr, Cy, Bn; R3 = n-Bu, cycloproyl, t-Bu, Et, i-Pr, Cy, Bn; R2R3 = -(CH2)2O(CH2)2-] from 1,1-dibromoalkenes RCH=CBr2Me has been developed. The reactions proceed through a key process, the C(sp)-B bond oxidation of alkynyl boronate intermediates with Oxone. This protocol features broad substrate scope, good efficiency, and good functional group compatibility. Moreover, the synthetic practicability was demonstrated by easy gram-scale preparation and the synthesis of drug mols., e.g., diclofenac.
ChemistrySelect published new progress about Aliphatic acids Role: SPN (Synthetic Preparation), PREP (Preparation). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Synthetic Route of 104-01-8.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem