Pearson, Colin M. published the artcileA Regio- and Stereodivergent Synthesis of Homoallylic Amines by a One-Pot Cooperative-Catalysis-Based Allylic Alkylation/Hofmann Rearrangement Strategy, Category: isoquinoline, the main research area is perfluorophenyl alkanoate allyl electrophile alkanol tandem alkylation Hofmann rearrangement; methyl alkenyl carbamate diastereoselective enantioselective regioselective preparation; alkylation; amines; ammonium enolates; palladium; rearrangement.
A modular synthetic route to linear and branched homoallylic amines that operates through a sequential one-pot Lewis base/transition-metal catalyzed allylic alkylation/Hofmann rearrangement strategy. This protocol was operationally trivial, proceeded from simple and easily prepared substrates and catalysts and enabled all aspects of regio- and stereoselectivity to be controlled through a conserved exptl. protocol. Overall, the high levels of enantio-, regio- and diastereoselectivity obtained, in concert with the ability to access orthogonally protected or free amines, render this a straightforward and effective approach for the preparation of useful enantioenriched homoallylic amines. The utility of the products in the context of pharmaceutical synthesis were also demonstrated.
Angewandte Chemie, International Edition published new progress about Aliphatic alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Category: isoquinoline.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem