Kang, Zhenghui published the artcilePrivilege-Structure-Oriented Three-Component Asymmetric Aminomethylation: Assembly of Chiral 3-Aminomethyl Indolones, Computed Properties of 151-10-0, the main research area is diazooxindole arene acetal dirhodium phosphoric acid chiral aminomethylation catalyst; indolone aminomethyl stereoselective preparation.
The asym. aminomethylation reaction of 3-diazooxindoles with electronic-rich arenes and N,O-acetals cooperatively catalyzed by achiral dirhodium complex and chiral phosphoric acid is reported. The reaction provides a novel method for the facile synthesis of chiral 3-aminomethyl oxindoles with an all-carbon quaternary center in good yields (82-98%) with high to excellent enantioselectivities (up to 97% ee). The transformation proceeds through a convergent addition of a reactive zwitterionic intermediate with a chiral methylene iminium generated in situ via asym. counteranion-directed catalysis (ACDC). This work represents the first asym. aminomethylation method of mixed 3,3′-bisindoles with structural diversity.
Organic Letters published new progress about Acetals Role: RCT (Reactant), RACT (Reactant or Reagent) (N,O-). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Computed Properties of 151-10-0.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem