Chen, Jian-Qiang published the artcileEfficient access to aliphatic esters by photocatalyzed alkoxycarbonylation of alkenes with alkyloxalyl chlorides, Application of 4-Methoxy-N-methylaniline, the main research area is ester preparation; alkene alkyloxalyl chloride alkoxycarbonylation photocatalyst.
A strategy to access aliphatic esters RC(O)OR1 (R = 2-chloro-2-(4-methylphenyl)ethyl, 2-chloroheptyl, 2-chloro-2-cyclohexylethyl, 2-chloro-3-(2,3-dihydro-1H-indol-1-yl)-2-methyl-3-oxopropyl, etc.; R1 = Et, 1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl, 4-phenylbutyl, etc.) from olefins RH through a photocatalyzed alkoxycarbonylation reaction was reported. Alkyloxalyl chlorides R1C(O)2C(O)Cl, generated in situ from the corresponding alcs. R1OH and oxalyl chloride, are engaged as alkoxycarbonyl radical fragments under photoredox catalysis. This transformation tolerates a broad scope of electron-rich and electron-deficient olefins and provides the corresponding β-chloro esters in good yields. Addnl., a formal β-selective alkene alkoxycarbonylation is developed. Moreover, a variety of oxindole-3-acetates I (R2 = H, t-Bu, CN, me, etc.; R3 = Me, Bn; R4 = Me, Et, Bn, i-Pr), Et 2-(1-methyl-2-oxo-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)acetate, Et 2-(7-methyl-6-oxo-1,2,3,4,6,7-hexahydroazepino[3,2,1-hi]indol-7-yl)acetate, Et 2-(1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzo[g]indol-3-yl)acetate and furoindolines II are prepared in good to excellent yields. A more concise formal synthesis of (±)-physovenine is accomplished as well. With these strategies, a wide range of natural-product-derived olefins and alkyloxalyl chlorides are also successfully employed.
Nature Communications published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Application of 4-Methoxy-N-methylaniline.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem