Scrivanti, Alberto published the artcileArylation of β-methallyl alcohol catalyzed by Pd(OAc)2 in combination with P(t-Bu)3: application to fragrance synthesis, Recommanded Product: 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, the main research area is arylmethylpropana helional canthoxal lilial preparation fragrance; methallyl alc arylation aryl bromide catalyst palladium phosphine.
Pd(OAc)2 in combination with P(t-Bu)3 catalyzes the coupling of β-methallyl alc. with 1-bromo-3,4-(methylenedioxy)benzene (I), 1-bromo-4-methoxybenzene (II), or 1-bromo-4-tert-butylbenzene (III). The reaction affords the corresponding 2-methyl-3-aryl-propanals, which are valuable floral fragrances. With I or II high reaction rates are obtained at 130 °C using NMP/water mixtures and an inorganic base such as Na2CO3. The chemoselectivity of the reaction is almost complete, so that the process appears practically feasible. In contrast, the coupling of β-methallyl alc. with III proceeds with low reaction rates.
Tetrahedron published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Recommanded Product: 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem