Shabalala, Nhlanhla Gracious published the artcileAn Efficient and Sustainable Protocol for the Synthesis of Poly-Functionalized-Pyran Derivatives under Ultrasound Irradiation, Safety of 2,3-Dimethoxybenzaldehyde, the main research area is benzaldehyde malononitrile dimedone three component one pot reaction ultrasonication; phenyl tetrahydrobenzopyran preparation green chem; barbituric acid benzaldehyde malononitrile three component one pot ultrasonication; tetrahydropyranopyrimidine phenyl preparation green chem.
A highly efficient and catalyst-free green synthetic protocol was developed for the synthesis of two series of poly-functionalized pyran derivatives I [R = 2-Cl, 3-OH-4-MeO, 2,4,6-tri-MeO, etc.] and II [R1 = 2-Cl, 2-NO2, 2-Cl-6-F, 2-CF3, 2-Br] via the one-pot reaction of benzaldehydes, malononitrile and either dimedone or 1,3-di-Me barbituric acid with EtOH: H2O (1:1 volume/volume) as solvent under ultrasound irradiation Excellent yields (90-99%) of desired pyran derivatives I and II were obtained for rapid reaction time 5 min. The structural features of the synthesized compounds I and II were fully characterized by spectroscopic techniques (IR, HRMS 1H and 13C NMR). A simple workup, clean reaction profile, short reaction times, excellent yields, 95% atom economy, and 100% carbon efficiency are the benefits of the proposed protocol. In addition, the circumvention of the chromatog. separations is the further advantage of the procedure.
Polycyclic Aromatic Compounds published new progress about Benzaldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Safety of 2,3-Dimethoxybenzaldehyde.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem