Liu, Yafei published the artcileA copper-catalyzed approach for the synthesis of asymmetrical disubstituted 1,2,4-thiadiazoles via elemental sulfur-mediated decarboxylative redox cyclization, SDS of cas: 104-01-8, the main research area is thiadiazole preparation; arylacetic acid amidine decarboxylative redox cyclization copper catalyst.
The various asym. disubstituted 1,2,4-thiadiazoles I (R = Ph, 2,5-dimethylphenyl, naphthalen-2-yl, thiophen-2-yl, etc.; R1 = H, Me, CF3, Ph) are smoothly prepared by copper-catalyzed approach, which employed arylacetic acids RCH2C(O)OH and amidines 4-R1C6H4C(=NH.HCl)NH2 as substrates, and elemental sulfur to mediate decarboxylative redox cyclization. The advantages of this method are simple, efficient, and ligand-free. In addition, this method can provide products I in moderate to good yields.
Tetrahedron Letters published new progress about Benzamidines Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, SDS of cas: 104-01-8.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem