Senthamarai, Thirusangumurugan published the artcileSimple ruthenium-catalyzed reductive amination enables the synthesis of a broad range of primary amines, Category: isoquinoline, the main research area is primary benzylic heterocyclic aliphatic amine preparation; aldehyde ketone reductive amination ruthenium catalyst.
The production of primary benzylic and aliphatic amines, which represent essential feedstocks and key intermediates for valuable chems., life science mols. and materials, is of central importance. Here, the synthesis of this class of amines starting from carbonyl compounds and ammonia by Ru-catalyzed reductive amination using H2 is reported. Key to success for this synthesis is the use of a simple RuCl2(PPh3)3 catalyst that empowers the synthesis of >90 various linear and branched benzylic, heterocyclic, and aliphatic amines under industrially viable and scalable conditions. Applying this catalyst, -NH2 moiety has been introduced in functionalized and structurally diverse compounds, steroid derivatives and pharmaceuticals. Noteworthy, the synthetic utility of this Ru-catalyzed amination protocol has been demonstrated by upscaling the reactions up to 10 g-scale syntheses. Furthermore, in situ NMR studies were performed for the identification of active catalytic species. Based on these studies a mechanism for Ru-catalyzed reductive amination is proposed.
Nature Communications published new progress about Amines Role: SPN (Synthetic Preparation), PREP (Preparation). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Category: isoquinoline.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem