22246-04-4, 7-Methoxy-3,4-dihydroisoquinolin-1(2H)-one is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example IX: Synthesis of l-(7-butoxy-2-isopropyl-l,2,3,4-tetrahydro-isoquinoIin-4- yl)-cyclohexanol; Step 1: Synthesis of 2-isopropyl-7-methoxy-3,4-dihydro-2H-isoquinolin-l-one; To a slurry of sodium hydride (671 mg, 27.97 mmol) in tetrahydrofuran (5 mL) was added 7-methoxy-3,4-dihydro-2/J-isoquinolin-l-one, obtained in example IV (step 2), in tetrahydrofuran (5 ml) and isopropyl iodide (1.40 ml, 13.98 mmol). The reaction mixture was stirred for 1 h at 80 0C. The reaction mixture was quenched with water (15 mL) and extracted with EtOAc (3×30 mL). The combined organic layer was washed with water (2×30 mL) and brine (30 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure to give crude material which was purified by column chromatography (silica gel, 2:98 MeOH : CHCl3) to yield the title compound (1.62 g, 79 %) as viscous liquid.ESIMS (m/z): 219.3 (M+l), 22246-04-4
The synthetic route of 22246-04-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; PANACEA BIOTEC LIMITED; WO2009/118765; (2009); A2;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem