DiPucchio, Rebecca C. published the artcileExploiting Natural Complexity: Synthetic Terpenoid-Alkaloids by Regioselective and Diastereoselective Hydroaminoalkylation Catalysis, Application In Synthesis of 5961-59-1, the main research area is regioselective diastereoselective hydroaminoalkylation limonene pinene aniline tantalum urea catalyst.
We report a catalytic and atom-economic approach for the addition of N-Me groups to unactivated alkene-containing terpenes to generate a library of synthetic terpenoid-alkaloids. This catalysis was accomplished using Ta(CH2SiMe3)3Cl2 in combination with a new chiral ureate salt, I, for highly chemo-, regio-, and diastereoselective hydroaminoalkylation reactions. The desired products are easily isolated and purified from unreacted starting materials to give aminated terpenes, e.g., II, in one catalytic step. Starting material enantiopurity is completely retained and stereoselective catalysis results give enantiopure products. Absolute stereochem. was determined by X-ray crystallog. and is consistent with regio- and stereoselective alkene insertion into a catalytically active tantallaziridine intermediate.
ChemCatChem published new progress about Aminoalkylation (hydro-, stereoselective, regioselective). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Application In Synthesis of 5961-59-1.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem