Nishimura, Rodolfo H. V. published the artcileEfficient N-arylation of 4-chloroquinazolines en route to novel 4-anilinoquinazolines as potential anticancer agents, COA of Formula: C8H11NO, the main research area is halophenyl anilinoquinazoline preparation microwave irradiation green chem antitumor human; chloroquinazoline aniline arylation; 4-anilinoquinazoline; 4-chloroquinazoline; N-arylation; anticancer agents; microwave irradiation.
Microwave-mediated N-arylation of 4-chloroquinazolines in THF/H2O rapidly and efficiently afforded a library of novel 6-halo-2-phenyl-substituted 4-anilinoquinazolines. The methodol. was compatible with numerous ortho-, meta-, and para-substituted N-methylanilines as well as substituted anilines and furnished the corresponding 4-anilinoquinazolines in good yields. Preliminary screening of the synthesized compounds against tumor cells (HCT-116 and T98G) showed promising antiproliferative properties.
Beilstein Journal of Organic Chemistry published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, COA of Formula: C8H11NO.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem