Wang, Lihong published the artcileVisible light-mediated NHCs and photoredox co-catalyzed radical 1,2-dicarbonylation of alkenes for 1,4-diketones, Quality Control of 86-51-1, the main research area is diketone preparation photocatalysis; alkene acyl fluoride alpha keto acid dicarbonylation NHC cocatalyst.
Dicarbonylation of alkenes provides direct access to value-added 1,4-dicarbonyl compounds However, selectivity control for unsym. 1,2-dicarbonylation is of great challenge. Herein authors describe NHCs and photocatalysis co-catalyzed three-component radical 1,2-dicarbonylation of alkenes by distinguishing two carbonyl groups, providing structurally diversified 1,4-diketones. Distinct properties of acyl radical and NHCs-stabilized ketyl radical contributed to selectivity control. Acyl radicals are rapidly added to alkenes delivering alkyl radicals, which underwent subsequent radical-radical cross-coupling with NHCs-stabilized ketyl-type radicals, affording 1,2-dicarbonylation products. This transformation features mild reaction conditions, broad substrate scope, and excellent selectivity, providing a general and practical approach for the dicarbonylation of olefins.
Science China: Chemistry published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Quality Control of 86-51-1.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem