Xu, Haiwei published the artcileDesign and synthesis of novel butenolide derivatives and inducing apoptosis in gastric cancer cells, Computed Properties of 86-51-1, the main research area is uncinine preparation antitumor gastric cancer; morpholinomethylbutenolide preparation diastereoselective antitumor apoptosis structure activity.
A new method of preparation for natural product uncinine was reported. According to the method, a series of novel butenolides derivatives I (X = O, CH2, NCH3), II (R = Me, OMe, n = 0, 1) and III [R1 = phenylmethylidene, thiophen-2-ylmethylidene, [3-fluoro-4-(4-methylpiperazin-1-yl)phenyl]methylidene, etc.] were designed and synthesized based on the natural product Uncinine. Most of the synthetic compounds showed significant antiproliferation activity against MGC-803. Among of them, III [R1 = (4-tert-butylphenyl)methylidene] (IV) showed a potent anticancer effect with IC50 of 2.9μmol/L in gastric cancer cell MGC803 and showed good selectivity to gastric cancer cells MGC803, HGC27, SGC7901 and less cytotoxicity in a normal gastric epithelial cell line (GES1). The research on the mol. level suggests that the mechanism of compound IV inducing apoptosis in gastric cancer cells is partially dependent on activation of caspase-9/3.
Youji Huaxue published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Computed Properties of 86-51-1.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem