Li, Yong published the artcileMicrowave-assisted efficient and facile synthesis of tetramic acid derivatives via a one-pot post-Ugi cascade reaction, Recommanded Product: 4-Methoxyphenylacetic acid, the main research area is tetramic acid derivative preparation microwave irradiation; ethyl glyoxylate amine acid isonitrile tandem Ugi Dieckmann cyclization; Dieckmann cyclization; Ugi reaction; multicomponent reactions; nitrogen heterocycles; one-pot reaction.
A facile microwave-assisted method for the synthesis of tetramic acid derivatives I (R1 = Ph, Bn, 4-MeOC6H4, etc.; R2 = 3-F, 4-NO2, 3,4-(OMe)2, etc.; R3 = Ph, Bn, c-hexyl, 2,6-(Me)2C6H3) has been developed through an Ugi/Dieckmann cyclization strategy with DBU. This two-step one-pot procedure afforded the targeted tetramic acid analogs in good yields. With com. available Ugi starting materials, microwave irradiation, a simple operation, excellent yields, and a broad scope, this reaction has the potential to produce a large number of tetramic acid analogs, which cannot be easily accessed by the classic synthetic methods.
Beilstein Journal of Organic Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Recommanded Product: 4-Methoxyphenylacetic acid.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem