Knighton, Richard C. published the artcileSynthesis and Reactivity of a Bis-Strained Alkyne Derived from 1,1′-Biphenyl-2,2′,6,6′-tetrol, Application of 1,3-Dimethoxybenzene, the main research area is biphenyltetrol alkyne preparation; azide alkyne cycloaddition biphenyltetrol alkyne; peptide stapling biphenyltetrol alkyne.
The novel ‘double strained alkyne’ I has been prepared and evaluated in strain-promoted azide-alkyne cycloaddition (SPAAC) reactions with azides. The X-ray crystallog. structure of I, which was prepared in one step from 1,1′-biphenyl-2,2′,6,6′-tetrol, reveals the strained nature of the alkynes. Dialkyne I undergoes cycloaddition reactions with a number of azides, giving mixtures of regioisomeric products in excellent yields. The monoaddn. products were not observed or isolated from the reactions, suggesting that the second cycloaddition proceeds at a faster rate than the first, and this is supported by mol. modeling studies. Dialkyne I was successfully employed for ‘peptide stapling’ of a p53-based diazido peptide, whereby two azides are bridged to give a product with a stabilized conformation.
ACS Omega published new progress about Azide-alkyne 1,3-dipolar cycloaddition reaction. 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Application of 1,3-Dimethoxybenzene.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem