Hatt, H. published the artcileCloning, functional expression and characterization of a human olfactory receptor, Category: isoquinoline, the main research area is review olfactory receptor odorant recognition.
A review with 16 references The human olfactory system can recognize and discriminate a large number of different odorant mols. The detection of chem. distinct odorants begins with the binding of an odorant ligand to a specific receptor protein on the olfactory neuron cell surface. To address the problem of olfactory perception at a mol. level, we have cloned, functionally expressed and characterized the first human olfactory receptor (OR 17-40). Application of a mixture of hundred different odorants elicited a transient increase in intracellular calcium at HEK 293-cells which were transfected with a plasmid containing the receptor encoding DNA and a membrane import sequence. By subdividing the odorant mixture in smaller groups we could identify a single component which represented the only effective substance: helional. Testing some structurally closely related mols. we found only one other compound which also could activate the receptor: heliotropyl acetone. All other compounds tested were completely ineffective. These findings represent the beginning of mol. understanding of odorant recognition in humans.
Cellular and Molecular Biology (Paris) published new progress about Odor and Odorous substances (recognition). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Category: isoquinoline.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem