Liang, Lixin published the artcileCatalytic Asymmetric Alkynylation of 3,4-Dihydro-β-carbolinium Ions Enables Collective Total Syntheses of Indole Alkaloids, Formula: C9H10O3, the main research area is asym alkynylation carbolinium ion copper catalyst; indole alkaloid stereoselective total synthesis copper catalyst; alkynylation; copper catalysis; indole alkaloids; tetrahydro-β-carbolines; total synthesis.
Chiral tetrahydro-β-carboline (THβC) is not only a prevailing structural feature of many natural alkaloids but also a versatile synthetic precursor for a vast array of monoterpenoid indole alkaloids. Asym. synthesis of C1-alkynyl THβCs remains rarely explored and challenging. Herein, the authors describe the development of two complementary approaches for the catalytic asym. alkynylation of 3,4-dihydro-β-carbolinium ions with up to 96% yield and 99% ee. The utility of chiral C1-alkynyl THβCs was demonstrated by the collective total syntheses of seven indole alkaloids: harmicine, eburnamonine, desethyleburnamonine, larutensine, geissoschizol, geissoschizine, and akuammicine.
Angewandte Chemie, International Edition published new progress about Alkynylation catalysts (stereoselective). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Formula: C9H10O3.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem