Warsitz, Michael published the artcileHydroaminoalkylation/Buchwald-Hartwig Amination Sequences for the Synthesis of Novel Thieno- or Benzothieno-Annulated Tetrahydropyridines, Tetrahydroazasilines, and Tetrahydroazasilepines, Application In Synthesis of 5961-59-1, the main research area is thienopyridine thienoazasiline thienoazasilepine preparation; titanium catalyst regioselective hydroaminoalkylation bromothienyl alkene methylarylamine; tandem regioselective hydroaminoalkylation bromothienyl alkene methylarylamine Buchwald Hartwig amination.
New two-step procedures that include an initial regioselective intermol. hydroaminoalkylation of 2-allyl-, 2-allyldimethylsilyl-, or 2-dimethyl(vinyl)silyl-substituted 3-bromothiophenes or 3-bromobenzothiophenes with secondary amines and a subsequent intramol. Buchwald-Hartwig amination give direct access to structurally novel bicyclic heterocycles including tetrahydrothienopyridines, tetrahydrothienoazasilines, tetrahydrobenzothienoazasilines, and tetrahydrobenzothienoazasilepines such as I (X = CH2, Me2Si) and II. The hydroaminoalkylation reaction is catalyzed by a mono(aminopyridinato) titanium complex which delivers the branched hydroaminoalkylation products or in the case of vinylsilyl-substituted substrates, the use of a bis(aminopyridinato) titanium complex gives access to the linear regioisomers. While in the latter case, the hydroaminoalkylation products need to be purified prior to the palladium-catalyzed amination step, all other two-step sequences can be run as a one-pot procedure.
European Journal of Organic Chemistry published new progress about Aminoalkylation (hydro-, regioselective). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Application In Synthesis of 5961-59-1.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem