Chen, Hongyu published the artcileData-driven catalyst optimization for stereodivergent asymmetric synthesis by iridium/boron hybrid catalysis, Application In Synthesis of 104-01-8, the main research area is allylic carboxylic acid stereodivergent enantioselective regioselective chemoselective diastereoselective preparation; carboxylic acid stereodivergent enantioselective allylation iridium boron hybrid catalysis.
Here, the straightforward identification of asym. two-component iridium/boron hybrid catalyst systems for α-C-allylation of carboxylic acids was reported. Structural optimization of the chiral ligands for iridium catalysts was driven by mol.-field-based regression anal. with a dataset containing overall 32 mol. structures. The catalyst systems enabled selective access to all the possible isomers of chiral carboxylic acids bearing contiguous stereocenters. This chemoselective and stereodivergent, asym. catalysis was applicable to late-stage structural modifications of drugs and their derivatives
Cell Reports Physical Science published new progress about Allylation catalysts, stereoselective. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Application In Synthesis of 104-01-8.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem