With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4494-18-2,1-Isoquinolinecarboxaldehyde,as a common compound, the synthetic route is as follows.
The compound (80 mg) obtained in Example 47-3 was dissolved in methanol (5.0 ml) and added with the compound (59.9 mg) obtained in Example 63-1, followed by the addition of sodium cyanoborohydride (35.9 mg). Then, the reaction solution was adjusted to about pH 5 with acetic acid, followed by stirring at room temperature for 14 hours. The reaction solution was added with a saturated aqueous sodium bicarbonate solution and then extracted with chloroform. The organic layer was washed with saturated saline solution and then dried with anhydrous sodium sulfate. Subsequently, the solvent was distilled off. The resulting crude product was purified through silica gel column chromatography (chloroform/methanol) and treated with hydrochloric acid, thereby obtaining hydrochloride (97.1 mg) of the subject compound as a white solid. MS(FAB,Pos.):m/z=561[M+H]+1H-NMR(500MHz,DMSO-d6):delta=0.87(6H,t,J=7.4Hz),1.67-1.78(4H,m),2.86-2.93(4H,m),3.92(2H,s),4.25-4.26(2H,m),4.36(2H,s),4.78(2H,brs),7.57-7.65(6H,m),7.81-7.86(4H,m),7.95(1H,brs),8.11(1H,brs),8.23(1H,brs),8.48-8.52(1H,m),8.62(1H,d,J=6.2Hz),10.34(1H,s),10.48(1H,brs).
4494-18-2, As the paragraph descriping shows that 4494-18-2 is playing an increasingly important role.
Reference£º
Patent; Kureha Chemical Industry Co., Ltd.; EP1550657; (2005); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem