With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7651-81-2,Isoquinolin-3(2H)-one,as a common compound, the synthetic route is as follows.
Preparation 11; A mixture of 3-hydroxyisoquinoline (500 mg, 3.44 mmol) and ethyl methacrylate (1.29 mL, 10.3 mmol) in toluene (10 mL) in a sealed reaction vessel was heated at 170 C for 16 h. The reaction mixture was concentrated and the product purified by preparative HPLC. A fraction containing isomers A and B in a 3: 1 ratio (A: B), was obtained as an oil (284 mg, 32% yield). MS (E+) m/z : 260 (MH+) ; Liquid Chromatograph (“LC”) retention time (“Rt”): 2.41 min (broad). A second fraction containing isomers C and D in a 5: 1 ratio (C: D) was also obtained as a solid (502 mg, 56%). MS (E+) nzlz : 260 (MH+) ; LC retention time: 2.70 min (broad)., 7651-81-2
The synthetic route of 7651-81-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2005/73221; (2005); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem