With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.84468-15-5,Isoquinoline-5-sulfonyl chloride,as a common compound, the synthetic route is as follows.
a) (S)-4-{2-[4-(Isoquinoline-5-sulfonylamino)-pcarboxylic acid tert-butyl ester(S)-4-[2-(4-Amino-phenyl)-ethyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester (150 mg) was dissolved in tetrahydrofuran at room temperature before treatment withtriethylamine (129.8 mu) and isoquinoline-5-sulfonyl chloride (141.4 mg), the reaction mixture was then warmed to 50 C and stirred for 6 hours. Upon evaporation of the solvent in vacuo the residue was purified by flash column chromatography (Si02; hexane/EtOAc 3: 1) to afford title compound (S)-4- {2-[4-(isoquinoline-5-sulfonylamino)-phenyl]-ethyl} -2,2-dimethyl-oxazolidine- 3-carboxylic acid tert-butyl ester (155 mg) as a white solid. MS (ISP): 512.3 ([M+H]+). b) Isoquino line-5 -sulfonic acid [4-((S)-3 -amino-4-hydroxy-butyl)-phenyl] -amide
84468-15-5, The synthetic route of 84468-15-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; GALLEY, Guido; NORCROSS, Roger; POLARA, Alessandra; WO2011/57973; (2011); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem