With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6624-49-3,Isoquinoline-3-carboxylic acid,as a common compound, the synthetic route is as follows.
General procedure: The tail group containing dimer or trimer (0.266 mmol) wasdissolved in methanol (25 mL), to which Pd/C-10percent (60 mg) wasadded at 0 C under nitrogen with stirring. The reaction mixturewas hydrogenated at room temperature and atmospheric pressurefor 4 h. The catalyst was removed over Kieselguhr and the solventwas removed under reduced pressure to give the amine, which wasdissolved in DMF (1 mL, dry). The appropriate head group carboxylic acid (0.266 mmol) was dissolved in DMF (1 mL, dry) towhich HBTU (260 mg, 0.685 mmol) and triethylamine (50 mL) wereadded to the reaction mixture at room temperature with stirringand the reaction mixture was left standing at room temperatureovernight. The product was purified by HPLC (no work up required).Fractions containing the product were collected and freeze dried togive the required product.
The synthetic route of 6624-49-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Scott, Fraser J.; Khalaf, Abedawn I.; Giordani, Federica; Wong, Pui Ee; Duffy, Sandra; Barrett, Michael; Avery, Vicky M.; Suckling, Colin J.; European Journal of Medicinal Chemistry; vol. 116; (2016); p. 116 – 125;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem