Su, Yuan-Hsiao published the artcileSolution-phase parallel synthesis and screening of anti-tumor activities from fenbufen and ethacrynic acid libraries, Application In Synthesis of 117-96-4, the main research area is solution phase parallel synthesis fenbufen ethacrynic acid library preparation; amidation fenbufen ethacrynic amine carboxylic acid reactant; fenbufen ethacrynic acid library preparation antitumor agent.
The derivatives with fenbufen and ethacrynic acid core compounds was synthesized through a facial preparation of 1-amino-4-azidobutane. The subsequent coupling with 102 members of carboxylic acids afforded amide products. The in situ screening using colorimetric assay with 3-(4.5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide showed that fenbufen but not ethacrynic acid Bu amide members displayed the cytotoxicities to tumor cells substantially, including two human cell lines (MCF7 and A549) and two murine cell lines (C26 and TRAMP-C1). Three fenbufen analogs, e.g. I, II and III, were found to have a good anti-tumor activity comparable to cisplatin.
Bioorganic & Medicinal Chemistry Letters published new progress about Amidation (vs bioactivity). 117-96-4 belongs to class isoquinoline, name is Diatrizoic Acid, and the molecular formula is C11H9I3N2O4, Application In Synthesis of 117-96-4.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem