Du, Wei’s team published research in Organic Letters in 19 | CAS: 2058236-53-4

Organic Letters published new progress about 2058236-53-4. 2058236-53-4 belongs to isoquinoline, auxiliary class Mono-oxazoline Ligands, name is (S)-2-(Isoquinolin-1-yl)-4-phenyl-4,5-dihydrooxazole, and the molecular formula is C18H14N2O, Synthetic Route of 2058236-53-4.

Du, Wei published the artcileEnantioselective Palladium-Catalyzed Oxidative Cascade Cyclization of Aliphatic Alkenyl Amides, Synthetic Route of 2058236-53-4, the publication is Organic Letters (2017), 19(2), 316-319, database is CAplus and MEDLINE.

The catalyst system of Pd(TFA)2/(S,S)-diPh-pyrox is reported to promote the highly efficient enantioselective oxidative cascade cyclization of alkene-tethered aliphatic acrylamides under mild aerobic conditions. Pyrrolizidine derivatives were synthesized in good yield and excellent enantioselectivity. D-labeling experiments revealed that the reaction proceeded through an anti-aminopalladation (anti-AP) pathway with high selectivity. The transition states for the anti-AP step account for the observed enantioselectivity.

Organic Letters published new progress about 2058236-53-4. 2058236-53-4 belongs to isoquinoline, auxiliary class Mono-oxazoline Ligands, name is (S)-2-(Isoquinolin-1-yl)-4-phenyl-4,5-dihydrooxazole, and the molecular formula is C18H14N2O, Synthetic Route of 2058236-53-4.

Referemce:
https://en.wikipedia.org/wiki/Isoquinoline,
Isoquinoline | C9H7N – PubChem