Duncton, Matthew A. J. published the artcileArylphthalazines as potent, and orally bioavailable inhibitors of VEGFR-2, Computed Properties of 371766-08-4, the publication is Bioorganic & Medicinal Chemistry (2009), 17(2), 731-740, database is CAplus and MEDLINE.
A series of arylphthalazine derivatives were synthesized and evaluated as antagonists of VEGF receptor II (VEGFR-2). IM-094482 57, which was prepared in two steps from com. available starting materials, was found to be a potent inhibitor of VEGFR-2 in enzymic, cellular and mitogenic assays (comparable activity to ZD-6474). Addnl., 57 inhibited the related receptor, VEGF receptor I (VEGFR-1), and showed excellent exposure when dosed orally to female CD-1 mice.
Bioorganic & Medicinal Chemistry published new progress about 371766-08-4. 371766-08-4 belongs to isoquinoline, auxiliary class Isoquinoline,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is Isoquinolin-5-ylboronic acid, and the molecular formula is C9H8BNO2, Computed Properties of 371766-08-4.
Referemce:
https://en.wikipedia.org/wiki/Isoquinoline,
Isoquinoline | C9H7N – PubChem