The Dimeric Form of 1,3-Diaminoisoquinoline Derivative Rescued the Mis-splicing of Atp2a1 and Clcn1 Genes in Myotonic Dystrophy Type 1 Mouse Model was written by Matsumoto, Jun;Nakamori, Masayuki;Okamoto, Tatsumasa;Murata, Asako;Dohno, Chikara;Nakatani, Kazuhiko. And the article was included in Chemistry – A European Journal in 2020.Reference of 1215767-89-7 The following contents are mentioned in the article:
Expanded CUG repeat RNA in the dystrophia myotonia protein kinase (DMPK) gene causes myotonic dystrophy type 1 (DM1) and sequesters RNA processing proteins, such as the splicing factor muscleblind-like 1 protein (MBNL1). Sequestration of splicing factors results in the mis-splicing of some pre-mRNAs. Small mols. that rescue the mis-splicing in the DM1 cells have drawn attention as potential drugs to treat DM1. Herein we report a new mol. JM642 consisted of two 1,3-diaminoisoquinoline chromophores having an auxiliary aromatic unit at the C5 position. JM642 alternates the splicing pattern of the pre-mRNA of the Ldb3 gene in the DM1 cell model and Clcn1 and Atp2a1 genes in the DM1 mouse model. In vitro binding anal. by surface plasmon resonance (SPR) assay to the r(CUG) repeat and disruption of ribonuclear foci in the DM1 cell model suggested the binding of JM642 to the expanded r(CUG) repeat in vivo, eventually rescue the mis-splicing. This study involved multiple reactions and reactants, such as 5-Bromo-1,3-dichloroisoquinoline (cas: 1215767-89-7Reference of 1215767-89-7).
5-Bromo-1,3-dichloroisoquinoline (cas: 1215767-89-7) belongs to isoquinoline derivatives. Although isoquinoline derivatives can be synthesized by several methods, relatively few direct methods deliver the unsubstituted isoquinoline. Other industrial applications include their use as corrosion inhibitors, preservatives, and as solvents for resins and terpenes.Reference of 1215767-89-7
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem