Qin, Ling-yan published the artcileAn improved and practical synthesis of Fmoc Rink linker, HPLC of Formula: 151-10-0, the main research area is solid phase peptide synthesis Fmoc Rink linker solvent effect; hydroxybenzaldehyde ethyl bromoacetate oxidation Friedel Crafts acylation Lewis acid; hydrolysis reductive amination hydroxylamine hydrogenation zinc catalyst condensation fluorenylmethoxycarbonyl.
Fmoc Rink linker (Fmoc = 9-fluorenylmethoxycarbonyl) is a widely used peptide-resin linker in the solid-phase synthesis of peptide-amides. This paper describes an improved and practical eight-step synthetic approach for this compound in a 50% overall yield, using p-hydroxybenzaldehyde as the starting material. The procedure is operationally simple and amenable to scale-up synthesis.
Journal of Chemical Research published new progress about Condensation reaction. 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, HPLC of Formula: 151-10-0.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem