Li, Peijun published the artcileThe Direct Decarboxylative N-Alkylation of Azoles, Sulfonamides, Ureas, and Carbamates with Carboxylic Acids via Photoredox Catalysis, Category: isoquinoline, the main research area is alkyl heterocycle preparation; carboxylic acid azole decarboxylative alkylation photo catalyst.
A method for direct decarboxylative C-N coupling of carboxylic acids RC(O)OH (R = naphthalen-1-yl, 2-phenylpropan-2-yl, 1,2,3,4-tetrahydronaphthalen-1-yl, etc.) with a range of nitrogen nucleophiles, e.g., 5-(4-bromophenyl)-2H-1,2,3,4-tetrazol-2-yl has been described. This platform employs visible-light-mediated photoredox catalysis and an iodine(III) reagent to generate carbocation intermediates directly from aliphatic carboxylic acids via a radical-polar crossover mechanism. A variety of C-N bond-containing products, e.g., I are constructed from a diverse array of nitrogen heterocycles, including pyrazoles, imidazoles, indazoles, and purine bases. Furthermore, sulfonamides, ureas, and carbamates can also be utilized as a nucleophile to generate a selection of N-alkylated products. Notably, a two-step approach to construct free amines directly from the carboxylic acids is accomplished using Cbz-protected amine as a nucleophile.
Organic Letters published new progress about Alkylation catalysts. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Category: isoquinoline.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem