Chen, Wenchang published the artcileConcise syntheses of 13-methylprotoberberine and 13-methyltetrahydroprotoberberine alkaloids, Computed Properties of 86-51-1, the main research area is Pictet Spengler Friedel Crafts hydroxyalkylation dehydration oxidation enantioselective sequence; methylprotoberberine stereoselective preparation; methyltetrahydroprotoberberine stereoselective preparation; isoquinoline alkaloid one pot stereoselective preparation.
The concise syntheses of eight 13-methylprotoberberine (13-MePB) and eight enantioenriched 13-methyltetrahydroprotoberberine (13-MeTHPB) alkaloids have been achieved in a tactically modular fashion. This synthetic work features a one-pot metal-free Pictet-Spengler/Friedel-Crafts hydroxyalkylation/dehydration/oxidation sequence and a following highly enantioselective Ir-catalyzed hydrogenation. Given such brevity and modularity, our developed synthetic route would be greatly beneficial to the efficient syntheses of existing natural products and new fully synthetic variants of 13-MePB and 13-MeTHPB family.
Chinese Chemical Letters published new progress about Dehydration reaction. 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Computed Properties of 86-51-1.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem