Hwangbo, Nathan published the artcilePredictive Modeling of Alzheimer′s and Parkinson′s Disease Using Metabolomic and Lipidomic Profiles from Cerebrospinal Fluid, Name: 4-Methoxyphenylacetic acid, the main research area is cerebrospinal fluid metabolomic lipidomic profile Alzheimers Parkinsons disease; biomarker; cerebrospinal fluid; cross-sectional study; neurodegenerative disease; predictive modeling.
In recent years, metabolomics has been used as a powerful tool to better understand the physiol. of neurodegenerative diseases and identify potential biomarkers for progression. We used targeted and untargeted aqueous, and lipidomic profiles of the metabolome from human cerebrospinal fluid to build multivariate predictive models distinguishing patients with Alzheimers disease (AD), Parkinsons disease (PD), and healthy age-matched controls. We emphasize several statistical challenges associated with metabolomic studies where the number of measured metabolites far exceeds sample size. We found strong separation in the metabolome between PD and controls, as well as between PD and AD, with weaker separation between AD and controls. Consistent with existing literature, we found alanine, kynurenine, tryptophan, and serine to be associated with PD classification against controls, while alanine, creatine, and long chain ceramides were associated with AD classification against controls. We conducted a univariate pathway anal. of untargeted and targeted metabolite profiles and find that vitamin E and urea cycle metabolism pathways are associated with PD, while the aspartate/asparagine and c21-steroid hormone biosynthesis pathways are associated with AD. We also found that the amount of metabolite missingness varied by phenotype, highlighting the importance of examining missing data in future metabolomic studies.
Metabolites published new progress about Alzheimer disease. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Name: 4-Methoxyphenylacetic acid.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem