1350643-72-9, (S)-3-(1-Aminoethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of 100 mg (0.391 mmol) of tert-butyl 4-chloro-5,6-dihydro-7H-pyrrolo [2,3- d] pyrimidine- 7- carboxylate in a 5 mL microwave vial, 129 mg (0.430 mmol) of (S) -3- (1-aminoethyl) -8-chloro-2-phenylisoquinoline-1 (2H) -one obtained in Preparation Example 3 was dissolved in 3 mL of anhydrous toluene , 2.6 mg (0.012 mmol) of palladium (II) acetate (Pd (OAc) 2) 2,2′-bis (diphenylphosphino) -1,1′-binaphthalene ((+ -) – BINAP) 22 mg (0.035 mmol), 178 mg (0.547 mmol) of cesium carbonate (Cs2CO3) was added, and degassing was performed three times using argon gas. And the mixture was stirred at 85 for 15 hours. The reaction mixture was filtered under reduced pressure, and the organic layer was extracted with ethyl acetate and water. The organic layer was dried (Na2SO4), filtered and concentrated. The crude product was dissolved in dichloromethane and purified by column chromatography (SiO2, eluent: hexane – dichloromethane of 33% ethyl acetate) to give tert-butyl (S) -4 – ((1- (8-chloro-1-oxo-2-phenyl-l, 2-dihydroisoquinolin- Yl) ethyl) amino) -5,6-dihydro- 7H-pyrrolo [2,3-d] pyrimidine-7-carboxylate 120 mg (0.469 mmol, 59% yield) was obtained as a pale yellow solid., 1350643-72-9
The synthetic route of 1350643-72-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Korea Research Institute of Chemical Technology; Lee, Gay Hyung; Lim, Hee Jong; Cho, Hee Young; Park, Woo Kyu; Jung, Dae Young; (40 pag.)KR2017/74381; (2017); A;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem