61563-43-7,61563-43-7, Isoquinoline-8-carboxylic acid is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Compound 20: 8-[((2S)-2-Methyl-4-{[4-(trifluoromethyl)phenyl]sulfonyl}-1 – piperazinyl)carbonyl]isoquinoline hydrochloride To a solution of (3S)-3-methyl-1 -{[4-(trifluoromethyl)phenyl]sulfonyl}piperazine (may be prepared in a similar manner as described in Intermediate 16; 50 mg, 0.162 mmol) and 8-isoquinolinecarboxylic acid (28.1 mg, 0.162 mmol) in N,N- Dimethylformamide (DMF) (5 mL), was added HOBT (27.3 mg, 0.178 mmol), n- ethylmorpholine (0.045 mL, 0.357 mmol), and HBTU (67.7 mg, 0.178 mmol) in sequence. Solvent was removed under vacuum to leave an oil which was dissolved in 1 .7ml of 1 :1 DMSO/MeCN and purified by MDAP. Relevant fractions were combined and concentrated to leave a clear oil (32mg). The oil was dissolved in 5ml THF and 0.05ml of 5M aqueous HCI was added. The solvent was removed to give the title compound as a white solid (35 mg).LCMS (low pH) RT 0.92 min, m/z (ES) 464 [M+H]+ 1H NMR (400 MHz, MeOD) rotameric mixture 5 9.10 (1 H, m), 8.50 (1 H, m), 8.1 -7.88 (6H, m), 7.83 (1 H, m), 7.59 (1 H, m), 5.25-4.55 (3H, m), 4.0-3.4 (4H, m), 2.8-2.1 (2H, m), 1 .6-1 .1 (3H, m) ppm
The synthetic route of 61563-43-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; CONVERGENCE PHARMACEUTICALS LIMITED; HEER, Jag Paul; CRIDLAND, Andrew Peter; NORTON, David; WO2011/86377; (2011); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem