Popova, Svetlana A. published the artcileIsobornylchalcones as scaffold for the synthesis of diarylpyrazolines with antioxidant activity, Related Products of isoquinoline, the main research area is diarylpyrazoline isobornylchalcone scaffold antioxidant activity; Fe2+/ascorbate-initiated lipid peroxidation; antioxidant activity; diarylpyrazolines; isobornylchalcones.
The pyrazoline ring is defined as a “”privileged structure”” in medicinal chem. A variety of pharmacol. properties of pyrazolines is associated with the nature and position of various substituents, which is especially evident in diarylpyrazolines. Compounds with a chalcone fragment show a wide range of biol. properties as well as high reactivity which is primarily due to the presence of an α, β-unsaturated carbonyl system. At the same time, bicyclic monoterpenoids deserve special attention as a source of a key structural block or as one of the pharmacophore components of biol. active mols. A series of new diarylpyrazoline derivatives based on isobornylchalcones with different substitutes (MeO, Hal, NO2, N(Me)2) was synthesized. Antioxidant properties of the obtained compounds were comparatively evaluated using in vitro model Fe2+/ascorbate-initiated lipid peroxidation in the substrate containing brain lipids of laboratory mice. It was demonstrated that the combination of the electron-donating group in the para-position of ring B and OH-group in the ring A in the structure of chalcone fragment provides significant antioxidant activity of synthesized diarylpyrazoline derivatives
Molecules published new progress about Antioxidants. 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Related Products of isoquinoline.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem