80278-67-7, Isoquinoline-5-carbaldehyde is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
80278-67-7, To a room temperature solution of 2-(4-cyclohexylphenyl)cyclopropanecarbohydrazide (200 mg) in ethanol (20 mL), was added isoquinoline-5-carbaldehyde (122 mg, 0.77 mmol) and acetic acid (0.5 mL). The reaction mixture was then heated at 80 0C for 3 h, concentrated in vacuo and the residue diluted with water and extracted with EtOAc (2 x 20 mL). The layers were separated and then the combined organic layers were washed with a saturated NaHCO3 solution, dried over magnesium sulfate, filtered and concentrated in vacuo to obtain the crude product. The crude material was purified via column chromatography eluting with 2percent MeOH in dichloromethane to afford (.pound.)-2-(4- cyclohexylphenyl)-N’-(isoquinolin-5 -ylmethylene)cyclopropanecarbohydrazide (100 mg, 33 percent) as a white solid.1H NMR (500 MHz, CDCl3): delta 9.30-9.22(m, 1 H), 8.78-8.69 (m, 1 H), 8.58-8.49 (m, 1 H), 8.36-8.28 (m, 1 H), 8.18-8.09 (m, 1 H), 7.78-7.69 (m, 2 H), 7.18-7.10 (m, 5 H), 2.98- 2.92 (m, 1 H), 2.56-2.48 (m, 2 H), 1.86-1.75 (m, 6 H), 1.45-1.36(m, 4 H); MS: M+H: m/z = 398.3; and HPLC: 99 percent, (Condition-C).
80278-67-7 Isoquinoline-5-carbaldehyde 7016853, aisoquinoline compound, is more and more widely used in various fields.
Reference£º
Patent; ENVIVO PHARMACEUTICALS, INC.; RIPKA, Amy; SHAPIRO, Gideon; CHESWORTH, Richard; WO2010/6130; (2010); A2;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem