Ilyina, Irina V. published the artcileInfluenza antiviral activity of F- and OH-containing isopulegol-derived octahydro-2H-chromenes, COA of Formula: C9H10O3, the main research area is fluoro hydroxy octahydrochromene preparation isopulegol Prins influenza treatment; Antiviral; Chromene; Fluorine; Influenza; Monoterpene.
The authors synthesized fluoro- and hydroxy-containing octahydro-2H-chromenes by the Prins reaction starting from a monoterpenoid (-)-isopulegol and a wide range of aromatic aldehydes in the presence of the BF3•Et2O/H2O system acting as both an acid catalyst and a fluorine source. Activity of the produced compounds against the influenza A/Puerto Rico/8/34 (H1N1) virus was studied. The highest activity was demonstrated by fluoro- and hydroxy-containing derivatives of 2,4,6-trimethoxybenzaldehyde. The most pronounced virus-inhibiting effect of compounds 10i and 11i was observed at an early stage of infection. These compounds were supposed to be capable of binding to viral hemagglutinin, which is an agreement with data on the effect of compounds 10i and 11i on the viral fusogenic activity as well as by mol. docking studies.
Bioorganic & Medicinal Chemistry Letters published new progress about Antiviral agents. 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, COA of Formula: C9H10O3.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem