Zheng, Cameron H. M. published the artcileThe Catalytic Synthesis of N-Aryl Indoles Featuring an Alternative Disconnection. Hydroaminoalkylation for a Telescoped Reaction Sequence, Product Details of C8H11NO, the main research area is aryl indole preparation; chlorostyrene methylaniline hydroaminoalkylation tantalumureate catalyst.
A tricatalytic telescoped synthesis toward C3-methyl-N-aryl indolines I (R = cyclohexyl, Ph, 3,4-dimethoxyphenyl, 2-phenylethyl, etc.) and indoles II products is reported. An in situ generated tantalum(V) ureate catalyst is used for the hydroaminoalkylation of o-chlorostyrene with N-Me aniline RNHCH3 to first make a Csp3-Csp3 bond. Subsequent nickel-catalyzed C-N coupling forms N-aryl indolines I, and if desired, subsequent oxidation to N-aryl indoles II can be achieved using catalytic [Cu(MeCN)4]BF4 and tert-butylperoxy-2-ethylhexyl carbonate as the terminal oxidant. This strategy highlights an alternative C-C bond disconnection for the synthesis of indoles II, which is enabled by the atom-economic hydroaminoalkylation reaction. The method was streamlined using a three-step, two-pot approach to afford up to 73% overall isolated yield of variously substituted C3-methyl-N-aryl indoles II.
Organic Letters published new progress about Aminoalkylation. 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Product Details of C8H11NO.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem