Kaniskan, H. Umit et al. published their research in Journal of Medicinal Chemistry in 2018 | CAS: 23707-37-1

Isoquinolin-7-amine (cas: 23707-37-1) belongs to isoquinoline derivatives. Quinoline and its derivatives are widely used as fungicides, biological agents, antibiotics, alkaloids, dyes, rubber chemicals and flavoring agents. It protonates to form salts upon treatment with strong acids, such as HCl. It forms adducts with Lewis acids, such as BF3.Quality Control of Isoquinolin-7-amine

Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3) was written by Kaniskan, H. Umit;Eram, Mohammad S.;Zhao, Kehao;Szewczyk, Magdalena M.;Yang, Xiaobao;Schmidt, Keith;Luo, Xiao;Xiao, Sean;Dai, Miao;He, Feng;Zang, Irene;Lin, Ying;Li, Fengling;Dobrovetsky, Elena;Smil, David;Min, Sun-Joon;Lin-Jones, Jennifer;Schapira, Matthieu;Atadja, Peter;Li, En;Barsyte-Lovejoy, Dalia;Arrowsmith, Cheryl H.;Brown, Peter J.;Liu, Feng;Yu, Zhengtian;Vedadi, Masoud;Jin, Jian. And the article was included in Journal of Medicinal Chemistry in 2018.Quality Control of Isoquinolin-7-amine This article mentions the following:

PRMT3 catalyzes the asym. dimethylation of arginine residues of various proteins. It is crucial for maturation of ribosomes, and has been implicated in several diseases. We recently disclosed a highly potent, selective and cell-active allosteric inhibitor of PRMT3, compound 4. Here, we report comprehensive structure-activity relationship studies that target the allosteric binding site of PRMT3. We conducted design, synthesis and evaluation of novel compounds in biochem., selectivity and cellular assays that culminated in the discovery of 4 and other highly potent (IC50 values: ∼10-36 nM), selective and cell-active allosteric inhibitors of PRMT3 (compounds 29, 30, 36 and 37). In addition, we generated compounds that are very close analogs of these potent inhibitors, but displayed drastically reduced potency as neg. controls (compounds 49-51). These inhibitors and neg. controls are valuable chem. tools for the biomedical community to further investigate biol. functions and disease associations of PRMT3. In the experiment, the researchers used many compounds, for example, Isoquinolin-7-amine (cas: 23707-37-1Quality Control of Isoquinolin-7-amine).

Isoquinolin-7-amine (cas: 23707-37-1) belongs to isoquinoline derivatives. Quinoline and its derivatives are widely used as fungicides, biological agents, antibiotics, alkaloids, dyes, rubber chemicals and flavoring agents. It protonates to form salts upon treatment with strong acids, such as HCl. It forms adducts with Lewis acids, such as BF3.Quality Control of Isoquinolin-7-amine

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem