Tetrahydro thiadiazolo isoquinolines: synthesis and inhibition of phenylethanolamine-N-methyltransferase was written by Girard, Gerald R.;Bondinell, William E.;Hillegass, Leonard M.;Holden, Kenneth G.;Pendleton, Robert G.;Uzinskas, Irene. And the article was included in Journal of Medicinal Chemistry in 1989.Formula: C9H8N2 This article mentions the following:
A series of 7,8-fused heterocyclic tetrahydroisoquinolines were prepared and tested as inhibitors of rabbit adrenal phenylethanolamine-N-methyltransferase (PNMT). Thus, thiadiazolotetrahydroisoquinoline hydrochloride I was prepared from 7-chloro-8-nitroisoquinoline in approx. 8 steps, which included cyclization of the diazonium salt II. I is a potent inhibitor of PNMT (inhibiting concentration 3.3 × 10-8M). The effects of changes in mol. structure on PNMT inhibition are discussed. In the experiment, the researchers used many compounds, for example, Isoquinolin-7-amine (cas: 23707-37-1Formula: C9H8N2).
Isoquinolin-7-amine (cas: 23707-37-1) belongs to isoquinoline derivatives. Quinoline is a mancude organic heterobicyclic parent, an azaarene, an ortho-fused heteroarene and a member of isoquinolines. Lewis acid activation and nucleophilic attack can produce multiple regioisomers in quinolines and pyridines; isoquinolines generally only undergo attack at the 1-position.Formula: C9H8N2
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem