Enantioselective phosphonation of isoquinolines via chiral phosphoric acid-catalyzed dearomatization was written by Gao, Zhenhua;Guo, Yongbiao. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2022.Name: 4-Methoxyisoquinoline This article mentions the following:
An efficient and enantioselective phosphonation protocol for construction of chiral α-aminophosphonates and α-aminodiarylphosphine oxides has been developed based on chiral phosphoric acid-catalyzed dearomatization of isoquinolines. A series of chiral 1,2-dihydroisoquinolines with dimethoxy phosphoryl or diphenylphosphono substituents at the C1-position were constructed with good to excellent yields and enantioselectivities under mild reaction conditions. In the experiment, the researchers used many compounds, for example, 4-Methoxyisoquinoline (cas: 36034-54-5Name: 4-Methoxyisoquinoline).
4-Methoxyisoquinoline (cas: 36034-54-5) belongs to isoquinoline derivatives. Being an analog of pyridine, isoquinoline is a weak base, with a pKa of 5.14. The Pomeranz–Fritsch reaction provides a method for the preparation of isoquinoline. This reaction uses a benzaldehyde and aminoacetoaldehyde diethyl acetal, which in an acid medium react to form isoquinoline.Name: 4-Methoxyisoquinoline
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem