Schmidt reaction with benzocycloalkenones was written by Tomita, Masatsugu;Minami, Shinsaku;Uyeo, Shojiro. And the article was included in Journal of the Chemical Society [Section] C: Organic in 1969.Related Products of 22245-96-1 This article mentions the following:
Eighteen 1-indanones, 15 1-tetralones, 2 1-benzosuberanones, and 2 benzocyclobutenones, as well as 4 acetophenones, were subjected to the Schmidt reaction in sulfuric acid, polyphosphoric acid, or molten trichloroacetic acid, and the ratios of the resp. isomeric rearrangement products were determined The direction of the rearrangement in the Schmidt reaction with benzocyclobutenones and 1-indanones is strongly affected by the substituents in the aromatic ring in positions para or ortho to the carbonyl group, and by the acid medium used in the reaction. The same influence was observed to a lesser extent, but still markedly, with 1-tetralones. In ketones having a flexible structure, such as 1-benzosuberanones and acetophenones, no appreciable influence of substituents and acid media was noted on the direction of migration, giving in all cases predominantly N-aryl amide. In the experiment, the researchers used many compounds, for example, 7-Nitro-3,4-dihydroisoquinolin-1(2H)-one (cas: 22245-96-1Related Products of 22245-96-1).
7-Nitro-3,4-dihydroisoquinolin-1(2H)-one (cas: 22245-96-1) belongs to isoquinoline derivatives. Quinoline is a catabolite of tryptophan, the basic structure of some antihypertensive drugs, such as the peripheral vasodilators prazosin and doxazosin. Other industrial applications include their use as corrosion inhibitors, preservatives, and as solvents for resins and terpenes.Related Products of 22245-96-1
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem